You get following error output by ntpd and docker in CentOS 7

Dec 2 16:12:11 server1 ntpd[xxxx]: ./../lib/isc/unix/interfaceiter.c:248: unexpected error:
Dec 2 16:12:11 server1 ntpd[xxxx]: br-22eee3e444b: getting interface flags: No such device

The above error message is harmless if ntpd is not listening on this interface. The best solution is to use chronyd, which is preferred and default in CentOS 7.